OWL Reasoners still useable in 2023

In a systematic literature and software review over 100 OWL reasoners/systems were analyzed to see if they would still be usable in 2023. This has never been done in this capacity. OWL reasoners still play an important role in knowledge organisation and management, but the last comprehensive surveys/studies are more than 8 years old. The result of this work is a comprehensive list of 95 standalone OWL reasoners and systems using an OWL reasoner. For each item, information on project pages, source code repositories and related documentation was gathered. The raw research data is provided in a Github repository for anyone to use

Repräsentation und Visualisierung von persönlichen Gewichtungen in semantischen Daten

In dieser Bachelorarbeit geht es darum herauszuarbeiten, wie die Gewichtung von Aussagen bei der Informationsinteraktion hilft. Mit Gewichtung ist in dem Zusammenhang die Zuordnung eines Wertes zu einer Aussage gemeint. Der Hauptteil der Arbeit beschäftigt sich mit der Anforderungsanalyse, der Spezifikation und Implementierung einer Komponente, welche die Gewichtung von Aussagen in Graphen visualisieren kann. Aufgrund der zeitlichen Einschränkung und des begrenzten Seitenumfangs beschränkt sich diese Arbeit auf eine Einführung in die Gewichtungsproblematik sowie die Erstellung eines Prototypen und der damit verbundenen Visualisierung verschiedener Gewichtungsalgorithmen. Hierbei geht es weder um die Ermittlung des besten Algorithmus zur Gewichtung von Aussagen, noch um die Interaktion mit großen Datenmengen

CubeViz.js: A Lightweight Framework for Discovering and Visualizing RDF Data Cubes

In this paper we present CubeViz.js, the successor of CubeViz, as an approach for lightweight visualization and exploration of statistical data using the RDF Data Cube vocabulary. In several use cases, such as the European Unions Open Data Portal, in which we deployed CubeViz, we were able to gather various requirements that eventually led to the decision of reimplementing CubeViz as JavaScript-only application. As part of this paper we showcase major functionalities of CubeViz.js and its improvements in comparison to the prior version

Hemodynamic evaluation of anesthetized baboons and piglets by transpulmonary thermodilution: Normal values and interspecies differences with respect to xenotransplantation

Background Transpulmonary thermodilution is well established as a tool for in-depth hemodynamic monitoring of critically ill patients during surgical procedures and intensive care. It permits easy assessment of graft function following cardiac transplantation and guides post-operative volume and catecholamine therapy. Since no pulmonary catheter is needed, transpulmonary thermodilution could be useful in experimental cardiac pig-to-baboon xenotransplantation. However, normal values for healthy animals have not yet been reported. Here, we present data from piglets and baboons before xenotransplantation experiments and highlight differences between the two species and human reference values. Methods Transpulmonary thermodilution from baboons (body weight 10-34 kg) and piglets (body weight 10-38kg) were analyzed. Measurements were taken in steady state after induction of general anesthesia before surgical procedures commenced. Cardiac index (CI), mean arterial pressure (MAP), systemic vascular resistance index (SVRI), parameters quantifying cardiac filling (global end-diastolic volume index, GEDI), and pulmonary edema (extravascular lung water, ELWI) were assessed. Results Preload, afterload, and contractility parameters clearly correlated with total body weight or body surface area. Baboons had lower CI values than weight-matched piglets (4.2 +/- 0.9l/min/m(2) vs 5.3 +/- 1.0/min/m(2), P < .01). MAP and SVRI were higher in baboons than piglets (MAP: 99 +/- 22 mm Hg vs 62 +/- 11 mm Hg, P < .01;SVRI: 1823 +/- 581 dyn*s/cm(5)*m(2) vs 827 +/- 204 dyn*s/cm(5)*m(2), P < .01). GEDI and ELWI did differ significantly between both species, but measurements were within similar ranges (GEDI: 523 +/- 103 mL/m(2) vs 433 +/- 78 mL/m(2), P < .01;ELWI: 10 +/- 3 mL/kg vs 11 +/- 2 mL/kg, P < .01). Regarding adult human reference values, CI was similar to both baboons and piglets, but all other parameters were different. Conclusions Parameters of preload, afterload, and contractility differ between baboons and piglets. In particular, baboons have a much higher afterload than piglets, which might be instrumental in causing perioperative xenograft dysfunction and post-operative myocardial hypertrophy after orthotopic pig-to-baboon cardiac xenotransplantation. Most transpulmonary thermodilution-derived parameters obtained from healthy piglets and baboons lie outside the reference ranges for humans, so human normal values should not be used to guide treatment in those animals. Our data provide reference values as a basis for developing algorithms for perioperative hemodynamic management in pig-to-baboon cardiac xenotransplantation

The clinical and genetic spectrum of autosomal-recessive TOR1A-related disorders.

In the field of rare diseases, progress in molecular diagnostics led to the recognition that variants linked to autosomal-dominant neurodegenerative diseases of later onset can, in the context of biallelic inheritance, cause devastating neurodevelopmental disorders and infantile or childhood-onset neurodegeneration. TOR1A-associated arthrogryposis multiplex congenita 5 (AMC5) is a rare neurodevelopmental disorder arising from biallelic variants in TOR1A, a gene that in the heterozygous state is associated to torsion dystonia-1 (DYT1 or DYT-TOR1A), an early-onset dystonia with reduced penetrance. While 15 individuals with TOR1A-AMC5 have been reported (less than 10 in detail), a systematic investigation of the full disease-associated spectrum has not been conducted. Here, we assess the clinical, radiological and molecular characteristics of 57 individuals from 40 families with biallelic variants in TOR1A. Median age at last follow-up was 3 years (0-24 years). Most individuals presented with severe congenital flexion contractures (95%) and variable developmental delay (79%). Motor symptoms were reported in 79% and included lower limb spasticity and pyramidal signs, as well as gait disturbances. Facial dysmorphism was an integral part of the phenotype, with key features being a broad/full nasal tip, narrowing of the forehead and full cheeks. Analysis of disease-associated manifestations delineated a phenotypic spectrum ranging from normal cognition and mild gait disturbance to congenital arthrogryposis, global developmental delay, intellectual disability, absent speech and inability to walk. In a subset, the presentation was consistent with fetal akinesia deformation sequence with severe intrauterine abnormalities. Survival was 71% with higher mortality in males. Death occurred at a median age of 1.2 months (1 week - 9 years) due to respiratory failure, cardiac arrest, or sepsis. Analysis of brain MRI studies identified non-specific neuroimaging features, including a hypoplastic corpus callosum (72%), foci of signal abnormality in the subcortical and periventricular white matter (55%), diffuse white matter volume loss (45%), mega cisterna magna (36%) and arachnoid cysts (27%). The molecular spectrum included 22 distinct variants, defining a mutational hotspot in the C-terminal domain of the Torsin-1A protein. Genotype-phenotype analysis revealed an association of missense variants in the 3-helix bundle domain to an attenuated phenotype, while missense variants near the Walker A/B motif as well as biallelic truncating variants were linked to early death. In summary, this systematic cross-sectional analysis of a large cohort of individuals with biallelic TOR1A variants across a wide age-range delineates the clinical and genetic spectrum of TOR1A-related autosomal-recessive disease and highlights potential predictors for disease severity and survival

Repräsentation und Visualisierung von persönlichen Gewichtungen in semantischen Daten

In dieser Bachelorarbeit geht es darum herauszuarbeiten, wie die Gewichtung von Aussagen bei der Informationsinteraktion hilft. Mit Gewichtung ist in dem Zusammenhang die Zuordnung eines Wertes zu einer Aussage gemeint. Der Hauptteil der Arbeit beschäftigt sich mit der Anforderungsanalyse, der Spezifikation und Implementierung einer Komponente, welche die Gewichtung von Aussagen in Graphen visualisieren kann. Aufgrund der zeitlichen Einschränkung und des begrenzten Seitenumfangs beschränkt sich diese Arbeit auf eine Einführung in die Gewichtungsproblematik sowie die Erstellung eines Prototypen und der damit verbundenen Visualisierung verschiedener Gewichtungsalgorithmen. Hierbei geht es weder um die Ermittlung des besten Algorithmus zur Gewichtung von Aussagen, noch um die Interaktion mit großen Datenmengen

Repräsentation und Visualisierung von persönlichen Gewichtungen in semantischen Daten

In dieser Bachelorarbeit geht es darum herauszuarbeiten, wie die Gewichtung von Aussagen bei der Informationsinteraktion hilft. Mit Gewichtung ist in dem Zusammenhang die Zuordnung eines Wertes zu einer Aussage gemeint. Der Hauptteil der Arbeit beschäftigt sich mit der Anforderungsanalyse, der Spezifikation und Implementierung einer Komponente, welche die Gewichtung von Aussagen in Graphen visualisieren kann. Aufgrund der zeitlichen Einschränkung und des begrenzten Seitenumfangs beschränkt sich diese Arbeit auf eine Einführung in die Gewichtungsproblematik sowie die Erstellung eines Prototypen und der damit verbundenen Visualisierung verschiedener Gewichtungsalgorithmen. Hierbei geht es weder um die Ermittlung des besten Algorithmus zur Gewichtung von Aussagen, noch um die Interaktion mit großen Datenmengen

CubeViz.js: A Lightweight Framework for Discovering and Visualizing RDF Data Cubes

In this paper we present CubeViz.js, the successor of CubeViz, as an approach for lightweight visualization and exploration of statistical data using the RDF Data Cube vocabulary. In several use cases, such as the European Unions Open Data Portal, in which we deployed CubeViz, we were able to gather various requirements that eventually led to the decision of reimplementing CubeViz as JavaScript-only application. As part of this paper we showcase major functionalities of CubeViz.js and its improvements in comparison to the prior version

CubeViz.js: A Lightweight Framework for Discovering and Visualizing RDF Data Cubes

In this paper we present CubeViz.js, the successor of CubeViz, as an approach for lightweight visualization and exploration of statistical data using the RDF Data Cube vocabulary. In several use cases, such as the European Unions Open Data Portal, in which we deployed CubeViz, we were able to gather various requirements that eventually led to the decision of reimplementing CubeViz as JavaScript-only application. As part of this paper we showcase major functionalities of CubeViz.js and its improvements in comparison to the prior version